SCHEMBL21038431

SCHEMBL21038431

Cc1ccc2c(c1)C1(c3cc(Cl)ccc3-2)c2ccccc2C(C)(C)c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 6/20 0.43
AKR1A1 P14550 2/20 0.39
AKR1B1 P15121 2/20 0.39
S100A4 P26447 1/20 0.36
NPSR1 Q6W5P4 2/20 0.35
CASP3 P42574 1/20 0.35
RAB9A P51151 1/20 0.35
ATM Q13315 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
LMNA P02545 2/20 0.35
PGR P06401 2/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MDM2 Q00987 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22797700 0.94 PDK2 (0.42) PDK2AKR1A1AKR1B1S100A4NPSR1
SCHEMBL30805712 0.92 PDK2 (0.49) PDK2AKR1A1AKR1B1S100A4PGR
SCHEMBL20121806 0.90 PDK2 (0.49) PDK2AKR1A1AKR1B1S100A4NPSR1
SCHEMBL30805708 0.88 PDK2 (0.50) PDK2AKR1A1AKR1B1S100A4LMNA
SCHEMBL21037250 0.88 PDK2 (0.50) PDK2AKR1A1AKR1B1S100A4LMNA
SCHEMBL19977174 0.88 PDK2 (0.46) PDK2AKR1A1AKR1B1S100A4PGR
SCHEMBL25629567 0.86 PDK2 (0.51) PDK2NPSR1CASP3RAB9AATM
SCHEMBL16435207 0.83 PDK2 (0.42) PDK2AKR1A1AKR1B1S100A4TDP1
SCHEMBL25815179 0.82 PDK2 (0.41) PDK2AKR1A1AKR1B1S100A4NPSR1
SCHEMBL1922761 0.79 PDK2 (0.54) PDK2AKR1A1AKR1B1S100A4PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019103397-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 주식회사 두산 2019-05-31 WO disclosed