SCHEMBL210386

SCHEMBL210386

CC(=O)NCN[C@H](CS)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.59
MAPT P10636 2/20 0.59
THRB P10828 1/20 0.59
ALOX15 P16050 1/20 0.59
NFKB1 P19838 1/20 0.59
PTGS2 P35354 1/20 0.59
THPO P40225 1/20 0.59
RECQL P46063 1/20 0.59
BLM P54132 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
ACE P12821 1/20 0.44
ALDH1A1 P00352 1/20 0.38
FOLH1 Q04609 4/20 0.38
NPSR1 Q6W5P4 1/20 0.33
TGFBR1 P36897 1/20 0.32
PTGS1 P23219 1/20 0.32
SLC7A11 Q9UPY5 1/20 0.32
MAPK1 P28482 1/20 0.32
HIF1A Q16665 1/20 0.32
CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL467821 1.00 KDM4E (0.59) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL467823 1.00 KDM4E (0.59) KDM4EMAPTTHRBALOX15NFKB1
Hydrochloric Acid SCHEMBL11206313 0.98 KDM4E (0.57) KDM4EMAPTTHRBALOX15NFKB1
Trifluoroacetic Acid SCHEMBL9661438 0.90 KDM4E (0.49) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL18668768 0.85 KDM4E (0.46) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL1679687 0.83 KDM4E (0.47) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL205286 0.83 KDM4E (0.47) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL205287 0.83 KDM4E (0.47) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL10977192 0.83 KDM4E (0.54) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL4911424 0.82 KDM4E (0.57) KDM4EMAPTTHRBALOX15NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1307 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163262-B1 PHENYLALANINE DERIVATIVES US GOV HEALTH & HUMAN SERV (US) 2011-05-11 EP claimed
US-20080139456-A1 Macrocyclic Sh2 Domain Binding Inhibitors GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2008-06-12 US claimed
WO-2008067270-A1 MACROCYCLIC GRB2 SH2 DOMAIN-BINDING INHIBITORS GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2008-06-05 WO claimed
US-7226991-B1 inhibiting SH2 domain binding with a phosphoprotein; to inhibit proliferation of tumor cells; for inhibiting the growth of human breast cancer cells UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2007-06-05 US claimed
US-6977241-B2 SH2 domain binding inhibitors THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 2005-12-20 US claimed
US-20040048788-A1 Sh2 domain binding inhibitors DEPARTMENT OF HEALTH AND HUMAN SERVICES, UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, OF THE 2004-03-11 US claimed
EP-1383792-A2 SH2 DOMAIN BINDING INHIBITORS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2004-01-28 EP claimed
WO-2004003005-A2 SH2 DOMAIN BINDING INHIBITORS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2004-01-08 WO claimed
WO-2002016407-A2 SH2 DOMAIN BINDING INHIBITORS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2002-02-28 WO claimed
EP-1163262-A1 PHENYLALANINE DERIVATIVES THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2001-12-19 EP claimed
WO-2000056760-A1 PHENYLALANINE DERIVATIVES THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-09-28 WO claimed
US-20260146073-A1 T CELL RECEPTORS TARGETING MUTATED CDKN2A THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) 2026-05-28 US disclosed
EP-4748856-A2 COMPOSITIONS AND METHODS FOR TREATING CANCER WITH SELF-DRIVING CHIMERIC ANTIGEN RECEPTORS Lentigen Technology, Inc. (US) 2026-05-27 EP disclosed
EP-4743578-A2 THERAPY FOR ALPHA-1 ANTITRYPSIN DEFICIENCY Precigen, Inc. (US) 2026-05-20 EP disclosed
US-12630802-B2 Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2026-05-19 US disclosed
WO-1997008193-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY NOVARTIS AG (CH) 1997-03-06 WO disclosed
WO-1997007131-A1 ACYLATED OLIGOPEPTIDES CONTAINING PHOSPHOTYROSINE AS INHIBITORS OF PROTEIN TYROSINE KINASES NOVARTIS AG (CH) 1997-02-27 WO disclosed
EP-0495963-A4 IMPROVED HYPOGLYCEMICS 1993-09-01 EP disclosed
EP-0495963-A1 IMPROVED HYPOGLYCEMICS AMYLIN PHARMACEUTICALS, INC. (US) 1992-07-29 EP disclosed
WO-1992003148-A1 IMPROVED HYPOGLYCEMICS AMYLIN CORPORATION (US) 1992-03-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630802-B2 Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood CD274, PDCD1, CD74 KDM4E 4449/4885MAPT 1803/4885THRB 904/4885
US-20260146073-A1 T CELL RECEPTORS TARGETING MUTATED CDKN2A TP53, CD74, HLA-C KDM4E 1921/4885MAPT 4121/4885THRB 939/4885
US-20080139456-A1 Macrocyclic Sh2 Domain Binding Inhibitors ACP1, PPM1D, LASP1 KDM4E 1848/4885MAPT 4810/4885THRB 1052/4885
US-20040048788-A1 Sh2 domain binding inhibitors ACP1, PHLPP1, SORBS1 KDM4E 572/4885MAPT 4737/4885THRB 584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.