Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE6D | O43924 | 2/20 | 0.48 |
| ▸ | PDE6A | P16499 | 2/20 | 0.48 |
| ▸ | PDE6G | P18545 | 2/20 | 0.48 |
| ▸ | PDE6B | P35913 | 2/20 | 0.48 |
| ▸ | PDE6C | P51160 | 2/20 | 0.48 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 12/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22001387 | 0.83 | CHRM1 (0.70) | CHRM1 | |
| SCHEMBL16593499 | 0.83 | CHRM1 (0.70) | CHRM1 | |
| SCHEMBL21043474 | 0.81 | CHRM1 (0.53) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL22001174 | 0.80 | CHRM1 (0.56) | CHRM1TP53MAPT | |
| SCHEMBL22001185 | 0.79 | PDE10A (0.48) | CHRM1KLKB1PDE10A | |
| SCHEMBL21043475 | 0.77 | CHRM1 (0.54) | CHRM1 | |
| SCHEMBL16395263 | 0.74 | PDE7A (0.45) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL21043084 | 0.74 | NPC1 (0.47) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395658 | 0.74 | PDE6D (0.78) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16395292 | 0.74 | PDE6D (0.64) | PDE6DPDE6APDE6GPDE6BPDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |