Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 9/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19997527 | 0.89 | PDE10A (0.43) | PDE10AADORA2AADORA1P2RX7 | |
| SCHEMBL21043471 | 0.84 | CHRM1 (0.59) | CHRM1 | |
| SCHEMBL16593247 | 0.84 | CHRM1 (0.59) | CHRM1 | |
| SCHEMBL21042779 | 0.79 | PDE6D (0.48) | PDE10AKLKB1CHRM1 | |
| SCHEMBL21043065 | 0.71 | CHRM1 (0.62) | CHRM1 | |
| SCHEMBL16593241 | 0.69 | CHRM1 (0.62) | CHRM1 | |
| SCHEMBL21043048 | 0.69 | CHRM1 (0.62) | CHRM1 | |
| SCHEMBL16395011 | 0.68 | PDE6D (0.47) | PDE10AMETCHRM1 | |
| SCHEMBL21043474 | 0.67 | CHRM1 (0.53) | PDE10AMETCHRM1 | |
| SCHEMBL21043084 | 0.67 | NPC1 (0.47) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |