Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11542075 | 0.83 | CRHBP (0.68) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL15524258 | 0.82 | CRHBP (0.59) | CRHBPCRHR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL629014 | 0.82 | KCNH2 (0.52) | CRHBPCRHR2KCNH2ALDH1A1LMNA | |
| SCHEMBL3144616 | 0.82 | KCNH2 (0.52) | CRHBPCRHR2KCNH2ALDH1A1LMNA | |
| SCHEMBL20380500 | 0.82 | CRHBP (0.59) | CRHBPCRHR2KCNH2ALDH1A1LMNA | |
| SCHEMBL3158691 | 0.81 | KCNH2 (0.66) | CRHBPCRHR2KCNH2TMEM97SIGMAR1 | |
| SCHEMBL1802673 | 0.80 | CRHBP (0.60) | CRHBPCRHR2KCNH2ALDH1A1LMNA | |
| SCHEMBL19895209 | 0.80 | CRHBP (0.48) | CRHBPCRHR2KCNH2ALDH1A1LMNA | |
| SCHEMBL3574502 | 0.79 | HDAC1 (0.52) | ALDH1A1LMNASMN1; SMN2TMEM97SIGMAR1 | |
| SCHEMBL20582635 | 0.79 | CRHBP (0.47) | CRHBPCRHR2KCNH2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163767-B2 | Heterocyclic Janus Kinase 3 inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |