Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859549 | 1.00 | KDM4E (0.61) | KDM4EPKMCARM1PRMT6GPR119 | |
| SCHEMBL20245869 | 1.00 | KDM4E (0.61) | KDM4EPKMCARM1PRMT6GPR119 | |
| Hydrochloric Acid SCHEMBL21047384 | 0.99 | KDM4E (0.60) | KDM4EPKMCARM1PRMT6GPR119 | |
| Hydrochloric Acid SCHEMBL19859633 | 0.99 | KDM4E (0.60) | KDM4EPKMCARM1PRMT6GPR119 | |
| SCHEMBL4209884 | 0.94 | KDM4E (0.65) | KDM4EPKMCARM1PRMT6GPR119 | |
| SCHEMBL30544307 | 0.86 | KDM4E (0.48) | KDM4EPKMGPR119USP30JAK2 | |
| SCHEMBL30544343 | 0.86 | KDM4E (0.48) | KDM4EPKMGPR119USP30JAK2 | |
| SCHEMBL29223412 | 0.86 | KDM4E (0.48) | KDM4EPKMGPR119USP30JAK2 | |
| SCHEMBL18891231 | 0.85 | KDM4E (0.64) | KDM4EPKMGPR119RAB9AMEN1 | |
| SCHEMBL13876978 | 0.84 | KDM4E (0.56) | KDM4EPKMGPR119USP30JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | METAP2, DNPEP, FOLH1 | KDM4E 2394/4885PKM 1598/4885CARM1 1978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.