⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048003 | 1.00 | — | — | |
| SCHEMBL4117080 | 0.89 | PIK3CD (0.31) | — | |
| Hydrochloric Acid SCHEMBL15847474 | 0.87 | CD38 (0.31) | — | |
| SCHEMBL12385859 | 0.81 | — | — | |
| SCHEMBL12065407 | 0.78 | HRH3 (0.41) | — | |
| SCHEMBL22351904 | 0.78 | LIPA (0.36) | — | |
| SCHEMBL12384722 | 0.78 | LIPA (0.36) | — | |
| SCHEMBL24449570 | 0.76 | THRA (0.33) | — | |
| SCHEMBL25933141 | 0.76 | — | — | |
| SCHEMBL17284202 | 0.76 | MCHR1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479818-B2 | Treatment of fibrosis with IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2025-11-25 | — | — | US | disclosed |
| EP-3707126-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2025-05-14 | — | — | EP | disclosed |
| US-20250019369-A1 | N-(4-aminocyclohexyl)pyrimidine-4-carboxamide derivatives as CD38 inhibitors | Cerevance, Inc. (US) | 2025-01-16 | — | — | US | disclosed |
| US-20240425477-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2024-12-26 | — | — | US | disclosed |
| EP-4430034-A1 | N-(4-AMINOCYCLOHEXYL)PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES AS CD38 INHIBITORS | Cerevance, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| US-12071424-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2024-08-27 | — | — | US | disclosed |
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| US-20230271935-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| WO-2023084206-A1 | N-(4-AMINOCYCLOHEXYL)PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES AS CD38 INHIBITORS | CEREVANCE LTD (GB) | 2023-05-19 | — | — | WO | disclosed |
| US-10961218-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2021-03-30 | — | — | US | disclosed |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | CORNELL UNIVERSITY | 2020-12-17 | — | — | US | disclosed |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | CORNELL UNIVERSITY | 2020-12-17 | — | — | US | disclosed |
| WO-2020232403-A1 | TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020232401-A1 | COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| CN-111566089-A | IRE1 small molecule inhibitor | 康奈尔大学 | 2020-08-21 | — | — | CN | disclosed |
| US-10745379-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| US-10745379-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2019-06-06 | — | — | US | disclosed |