Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HAVCR2 | Q8TDQ0 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21054650 | 0.77 | ALDH1A1 (0.45) | GAAAPOBEC3GALDH1A1KDM4EHPGD | |
| SCHEMBL21053046 | 0.74 | ALDH1A1 (0.41) | GAAAPOBEC3GALDH1A1KDM4EHPGD | |
| SCHEMBL20068161 | 0.68 | ALDH1A1 (0.43) | GAAAPOBEC3GALDH1A1KDM4EHPGD | |
| SCHEMBL9640578 | 0.62 | POLB (0.56) | GAAAPOBEC3GALDH1A1KDM4EHPGD | |
| Water SCHEMBL7594637 | 0.61 | — | — | |
| SCHEMBL3678909 | 0.61 | KDM4E (0.39) | GAAAPOBEC3GALDH1A1KDM4EHPGD | |
| SCHEMBL3591108 | 0.59 | — | — | |
| SCHEMBL4919077 | 0.59 | ATM (0.55) | GAAAPOBEC3GALDH1A1KDM4EHPGD | |
| SCHEMBL14511650 | 0.59 | — | — | |
| SCHEMBL13182125 | 0.59 | MAPT (0.40) | GAAAPOBEC3GALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720860-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2020-10-14 | — | — | EP | disclosed |
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| CN-111433212-A | Positive allosteric modulators of muscarinic acetylcholine receptor M4 | 范德比尔特大学 | 2020-07-17 | — | — | CN | disclosed |
| WO-2019113179-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2019-06-13 | — | — | WO | disclosed |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM5, CHRM2 | GAA 3664/4885APOBEC3G 2935/4885ALDH1A1 3940/4885 |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | GAA 3664/4885APOBEC3G 2935/4885ALDH1A1 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.