SCHEMBL21048729

SCHEMBL21048729

CC(C)(C)CC(C(=O)O)C(=O)CC(=O)COCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.46
PPARA Q07869 2/20 0.42
CTSS P25774 3/20 0.41
CTSL P07711 1/20 0.41
CTSB P07858 1/20 0.41
MAPT P10636 2/20 0.40
PTPRC P08575 1/20 0.38
PTPN1 P18031 1/20 0.38
SLC1A1 P43005 1/20 0.38
PPARG P37231 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HTT P42858 1/20 0.37
FOLH1 Q04609 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
RAB9A P51151 1/20 0.37
TSHR P16473 1/20 0.37
GRM5 P41594 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21048731 0.85 NPC1 (0.49) NPC1PPARAMAPTPTPRCPTPN1
SCHEMBL21048735 0.82 NPC1 (0.47) NPC1PPARACTSSMAPTPTPRC
SCHEMBL21048734 0.80 NPC1 (0.50) NPC1PPARACTSBMAPTPTPRC
SCHEMBL6702666 0.77 TSHR (0.56) NPC1MAPTPTPRCPTPN1SMN1; SMN2
SCHEMBL14193390 0.76 NPC1 (0.51) NPC1PPARAMAPTSMN1; SMN2ALDH1A1
SCHEMBL9622282 0.75 NPC1 (0.52) NPC1MAPTPTPRCPTPN1SMN1; SMN2
SCHEMBL21482516 0.74 MAPT (0.48) NPC1MAPTPTPRCPTPN1ALDH1A1
SCHEMBL4545478 0.74 PPARA (0.48) NPC1PPARACTSSMAPTPPARG
SCHEMBL1987313 0.74 TSHR (0.52) NPC1MAPTPTPRCPTPN1SMN1; SMN2
SCHEMBL476827 0.74 TSHR (0.61) NPC1MAPTSLC1A1SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3141601-B1 DOUBLE-CARBONYL REDUCTASE MUTANT AND APPLICATION OF SAME ASYMCHEM LAB TIANJIN CO LTD (CN) 2019-06-12 EP claimed