Azepane

Azepane

SCHEMBL21049976

C1CCCNCC1.CN1CCCC1=O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.71
BRD2 P25440 1/20 0.71
ALDH1A1 P00352 3/20 0.38
INMT O95050 2/20 0.37
GAA P10253 4/20 0.35
KDM4E B2RXH2 2/20 0.35
POLB P06746 1/20 0.35
PIK3CD O00329 2/20 0.34
MEN1 O00255 3/20 0.34
MAPT P10636 3/20 0.34
KMT2A Q03164 3/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
USP2 O75604 1/20 0.34
LMNA P02545 1/20 0.34
IDE P14735 1/20 0.34
PSMD14 O00487 2/20 0.33
ACHE P22303 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylpyrrolidone SCHEMBL2781641 1.00 BRD4 (0.71) BRD4BRD2ALDH1A1INMTGAA
SCHEMBL7359128 0.94 BRD4 (0.61) BRD4BRD2ALDH1A1GAAKDM4E
Methylpyrrolidone SCHEMBL28165318 0.91 BRD4 (0.77) BRD4BRD2ALDH1A1INMTGAA
Methylpyrrolidone SCHEMBL28115455 0.87
SCHEMBL13259171 0.85 BRD4 (0.60) BRD4BRD2ALDH1A1INMTGAA
Methylpyrrolidone SCHEMBL11304311 0.84 BRD4 (0.90) BRD4BRD2ALDH1A1INMTGAA
Methylpyrrolidone SCHEMBL8055062 0.84 BRD4 (1.00) BRD4BRD2ALDH1A1INMTGAA
Methylpyrrolidone SCHEMBL487 0.84
Methylpyrrolidone SCHEMBL5423326 0.84
Methylpyrrolidone SCHEMBL1255511 0.84 BRD4 (1.00) BRD4BRD2ALDH1A1INMTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114502629-B Safety tyre 株式会社普利司通 2024-12-24 CN disclosed
EP-3725839-B1 RUBBER COMPOSITION AND TIRE USING SAME BRIDGESTONE CORP (JP) 2024-10-30 EP disclosed
CN-111492000-B Rubber composition and tire using same 株式会社普利司通 2023-02-17 CN disclosed
CN-114502629-A Safety tyre 株式会社普利司通 2022-05-13 CN disclosed
CN-114466888-A Rubber composition and run-flat tire 株式会社普利司通 2022-05-10 CN disclosed
WO-2021066099-A1 RUN-FLAT TIRE 株式会社ブリヂストン 2021-04-08 WO disclosed
WO-2021066106-A1 RUBBER COMPOSITION AND RUN-FLAT TIRE 株式会社ブリヂストン 2021-04-08 WO disclosed
EP-3725566-A1 TIRE Bridgestone Corporation (JP) 2020-10-21 EP disclosed
EP-3725839-A1 RUBBER COMPOSITION AND TIRE USING SAME Bridgestone Corporation (JP) 2020-10-21 EP disclosed
US-10793703-B2 Tire BRIDGESTONE CORPORATION (JP) 2020-10-06 US disclosed
US-20200299427-A1 RUBBER COMPOSITION AND TIRE USING SAME BRIDGESTONE CORPORATION (JP) 2020-09-24 US disclosed
CN-111492000-A Rubber composition and tire using same 株式会社普利司通 2020-08-04 CN disclosed
US-20190177515-A1 TIRE BRIDGESTONE CORPORATION (JP) 2019-06-13 US disclosed