Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.77 |
| ▸ | GCKR | Q14397 | 2/20 | 0.77 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15834 | 0.87 | GCK (1.00) | GCKGCKR | |
| SCHEMBL30956 | 0.87 | GCK (1.00) | GCKGCKR | |
| SCHEMBL16938 | 0.87 | GCK (1.00) | GCKGCKR | |
| SCHEMBL18023 | 0.81 | GCK (0.77) | GCKGCKRHSD11B1ALDH1A1 | |
| SCHEMBL15754 | 0.81 | GCK (0.77) | GCKGCKRHSD11B1ALDH1A1 | |
| SCHEMBL12079031 | 0.81 | GCK (0.77) | GCKGCKRHSD11B1ALDH1A1 | |
| SCHEMBL17056 | 0.81 | GCK (0.52) | GCKGCKRHSD11B1ALDH1A1CYP2D6 | |
| SCHEMBL17055 | 0.80 | GCKR (0.81) | GCKGCKR | |
| SCHEMBL12090032 | 0.80 | GCK (0.60) | GCKGCKRHSD11B1CYP2D6 | |
| SCHEMBL16509 | 0.76 | GCK (1.00) | GCKGCKR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |