Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 7/20 | 0.52 |
| ▸ | GCKR | Q14397 | 3/20 | 0.52 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.39 |
| ▸ | GLRB | P48167 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675 | 0.89 | GCK (0.67) | GCKGCKR | |
| SCHEMBL16932 | 0.89 | GCK (0.67) | GCKGCKR | |
| SCHEMBL18383 | 0.89 | GCK (0.67) | GCKGCKR | |
| SCHEMBL21050 | 0.81 | GCK (0.77) | GCKGCKRALDH1A1CYP2D6HSD11B1 | |
| SCHEMBL17687 | 0.80 | GCK (0.66) | GCKGCKR | |
| SCHEMBL15201362 | 0.79 | GCK (0.55) | GCKGCKR | |
| SCHEMBL15200890 | 0.79 | GCK (0.55) | GCKGCKR | |
| SCHEMBL15201628 | 0.79 | GCK (0.47) | GCKGCKRMLYCDCHRM1 | |
| SCHEMBL18058 | 0.78 | GCK (0.52) | GCKGCKR | |
| SCHEMBL16115 | 0.78 | GCK (0.52) | GCKGCKR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |