Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 6/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050441 | 1.00 | CYP2C19 (0.45) | CYP2C19PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL21050439 | 1.00 | CYP2C19 (0.45) | CYP2C19PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL18971121 | 0.85 | CYP2C19 (0.41) | CYP2C19PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL18952582 | 0.85 | CYP2C19 (0.41) | CYP2C19PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL18952584 | 0.85 | CYP2C19 (0.41) | CYP2C19PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL21050474 | 0.85 | CYP2C19 (0.41) | CYP2C19PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL21093907 | 0.85 | CYP2C19 (0.41) | CYP2C19PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL21050462 | 0.85 | PSEN1 (0.45) | PSEN1PSEN2KCNH2APH1BNCSTN | |
| SCHEMBL21050468 | 0.85 | PSEN1 (0.45) | PSEN1PSEN2KCNH2APH1BNCSTN | |
| SCHEMBL21050466 | 0.85 | PSEN1 (0.45) | PSEN1PSEN2KCNH2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319314-B2 | Phenoxytriazoles | HOFFMANN-LA ROCHE INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-20210309653-A1 | PHENOXYTRIAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2021-10-07 | — | — | US | disclosed |
| EP-3538516-B1 | PHENOXYTRIAZOLES | HOFFMANN LA ROCHE (CH) | 2021-06-16 | — | — | EP | disclosed |
| US-10730881-B2 | Fused pyrimidine derivatives | HOFFMANN-LA ROCHE, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190177329-A1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309653-A1 | PHENOXYTRIAZOLES | HTT, PSEN1, APP | CYP2C19 3576/4885PSEN1 2/4885PSEN2 7/4885 |
| US-10730881-B2 | Fused pyrimidine derivatives | APP, UPF1, PSEN1 | CYP2C19 3050/4885PSEN1 3/4885PSEN2 10/4885 |
| US-20190177329-A1 | FUSED PYRIMIDINE DERIVATIVES | APP, UPF1, PSEN1 | CYP2C19 3050/4885PSEN1 3/4885PSEN2 10/4885 |
| US-11319314-B2 | Phenoxytriazoles | HTT, APP, PSEN1 | CYP2C19 3156/4885PSEN1 3/4885PSEN2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.