SCHEMBL21055968

SCHEMBL21055968

N#Cc1ccc(Cl)c(C(=O)Nc2ccnc(-c3cccnc3)c2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARG P37231 6/20 1.00
PDGFRB P09619 2/20 0.52
PDGFRA P16234 2/20 0.52
ABL1 P00519 1/20 0.52
BCR P11274 1/20 0.52
PRKCA P17252 1/20 0.52
ATR Q13535 1/20 0.52
CSF1R P07333 8/20 0.49
BRAF P15056 1/20 0.48
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
CYP11B1 P15538 1/20 0.46
CYP11B2 P19099 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30436764 1.00 PPARG (1.00) PPARGPDGFRBPDGFRAABL1BCR
SCHEMBL30436926 0.90 PPARG (0.82) PPARG
SCHEMBL21055970 0.90 PPARG (0.82) PPARG
SCHEMBL21055975 0.88 PPARG (0.80) PPARG
SCHEMBL30436545 0.88 PPARG (0.80) PPARG
SCHEMBL21056003 0.88 PPARG (0.78) PPARGPDGFRBPDGFRAABL1BCR
SCHEMBL30436387 0.88 PPARG (0.78) PPARGPDGFRBPDGFRAABL1BCR
SCHEMBL21055976 0.88 PPARG (0.81) PPARGPDGFRBPDGFRAABL1BCR
SCHEMBL30436599 0.88 PPARG (0.81) PPARGPDGFRBPDGFRAABL1BCR
SCHEMBL21061694 0.87 PPARG (0.75) PPARGPDGFRBPDGFRAABL1BCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111630030-B Novel benzamide derivatives as PPAR-gamma modulators 梅迪比奥法尔玛公司 2023-06-20 CN claimed
US-11267808-B2 Benzamide derivatives as PPAR-gamma modulators MEDIBIOFARMA, S.L. (ES) 2022-03-08 US claimed
EP-3724165-B1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA S L (ES) 2022-01-12 EP claimed
US-20210171511-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2021-06-10 US claimed
EP-3724165-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2020-10-21 EP claimed
CN-111630030-A Novel benzamide derivatives as PPAR-gamma modulators 梅迪比奥法尔玛公司 2020-09-04 CN claimed
WO-2019115498-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2019-06-20 WO claimed
EP-3498694-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2019-06-19 EP claimed
CN-111630030-B Novel benzamide derivatives as PPAR-gamma modulators 梅迪比奥法尔玛公司 2023-06-20 CN disclosed
US-11267808-B2 Benzamide derivatives as PPAR-gamma modulators MEDIBIOFARMA, S.L. (ES) 2022-03-08 US disclosed
EP-3724165-B1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA S L (ES) 2022-01-12 EP disclosed
EP-3724165-B1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA S L (ES) 2022-01-12 EP disclosed
US-20210171511-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2021-06-10 US disclosed
US-20210171511-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2021-06-10 US disclosed
EP-3724165-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2020-10-21 EP disclosed
CN-111630030-A Novel benzamide derivatives as PPAR-gamma modulators 梅迪比奥法尔玛公司 2020-09-04 CN disclosed
WO-2019115498-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2019-06-20 WO disclosed
WO-2019115498-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2019-06-20 WO disclosed
EP-3498694-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2019-06-19 EP disclosed
EP-3498694-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS MEDIBIOFARMA, S.L. (ES) 2019-06-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210171511-A1 NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS PPARD, PPARG, PPARA PPARG 2/4885PDGFRB 18/4885PDGFRA 10/4885
US-11267808-B2 Benzamide derivatives as PPAR-gamma modulators PPARG, PPARD, PPARA PPARG 1/4885PDGFRB 10/4885PDGFRA 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.