Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMO | O15229 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21060112 | 0.83 | SMN1; SMN2 (0.32) | PTGER1SMN1; SMN2FABP4 | |
| SCHEMBL21060471 | 0.82 | HSP90AA1 (0.40) | LMNAPTGER1HTR6MAPTPIK3CA | |
| SCHEMBL29897152 | 0.82 | HSP90AA1 (0.40) | LMNAPTGER1HTR6MAPTPIK3CA | |
| SCHEMBL16593445 | 0.78 | PTGER4 (0.36) | SMN1; SMN2PTGER4HTR6HTT | |
| SCHEMBL29897163 | 0.73 | ELANE (0.44) | SMN1; SMN2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL29433116 | 0.69 | KDM4E (0.43) | MAPTALDH1A1HTT | |
| SCHEMBL24680131 | 0.68 | L3MBTL1 (0.39) | SMN1; SMN2MAPTFABP4PIK3CAALDH1A1 | |
| SCHEMBL23809294 | 0.68 | KDM4E (0.37) | MAPTL3MBTL1 | |
| SCHEMBL1564741 | 0.67 | MAOB (0.38) | SMN1; SMN2PTGER4HDAC8ALDH1A1L3MBTL1 | |
| SCHEMBL24742304 | 0.67 | KMT2A (0.39) | LMNAPTGER4HTR6MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111819176-B | 4-azaindole compounds | 百时美施贵宝公司 | 2023-12-15 | — | — | CN | disclosed |
| US-11820768-B2 | 4-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-11-21 | — | — | US | disclosed |
| EP-3728252-B1 | 4-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-09 | — | — | EP | disclosed |
| US-11053244-B1 | 4-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-06 | — | — | US | disclosed |
| CN-111819176-A | 4-azaindole compounds | 百时美施贵宝公司 | 2020-10-23 | — | — | CN | disclosed |
| US-10730877-B2 | 4-Azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-04 | — | — | US | disclosed |
| US-20200095247-A1 | 4-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-03-26 | — | — | US | disclosed |
| US-10544143-B2 | 4-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190185469-A1 | 4-AZAINDOLE COMPOUNDS | SYNGENE INTERNATIONAL LIMITED (IN) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11820768-B2 | 4-azaindole compounds | TLR7, TLR9, TLR5 | LMNA 3331/4885PTGER1 171/4885SMN1; SMN2 4225/4885 |
| US-11053244-B1 | 4-azaindole compounds | TLR7, TLR9, TLR5 | LMNA 3331/4885PTGER1 171/4885SMN1; SMN2 4225/4885 |
| US-10544143-B2 | 4-azaindole compounds | TLR7, TLR9, TLR5 | LMNA 3331/4885PTGER1 171/4885SMN1; SMN2 4225/4885 |
| US-10730877-B2 | 4-Azaindole compounds | TLR7, TLR9, TLR5 | LMNA 3331/4885PTGER1 171/4885SMN1; SMN2 4225/4885 |
| US-20190185469-A1 | 4-AZAINDOLE COMPOUNDS | TLR7, TLR9, TLR5 | LMNA 3331/4885PTGER1 171/4885SMN1; SMN2 4225/4885 |
| US-20200095247-A1 | 4-AZAINDOLE COMPOUNDS | TLR7, TLR9, TLR5 | LMNA 3331/4885PTGER1 171/4885SMN1; SMN2 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.