SCHEMBL21060804

SCHEMBL21060804

O=C(O)[C@@H](CF)Oc1ccc(Br)cc1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.59
PPARG P37231 18/20 0.59
PPARA Q07869 16/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21057201 1.00 LDHA (0.59) LDHAPPARGPPARA
SCHEMBL21057203 1.00 LDHA (0.59) LDHAPPARGPPARA
SCHEMBL21057169 0.88 LDHA (0.58) LDHAPPARGPPARA
SCHEMBL21057172 0.88 LDHA (0.58) LDHAPPARGPPARA
SCHEMBL30575130 0.86 PPARG (0.49) LDHAPPARGPPARA
SCHEMBL30575133 0.85 PPARG (0.44) LDHAPPARGPPARA
SCHEMBL30575129 0.85 PPARG (0.44) LDHAPPARGPPARA
SCHEMBL21057232 0.84 LDHA (0.61) LDHAPPARGPPARA
SCHEMBL21057234 0.84 LDHA (0.61) LDHAPPARGPPARA
SCHEMBL4187184 0.84 LDHA (0.61) LDHAPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190183833-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA APS 2019-06-20 US claimed
EP-3723745-B1 PHENOXY ACIDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA AS (DK) 2024-06-19 EP disclosed
US-11730714-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2023-08-22 US disclosed
US-11730714-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2023-08-22 US disclosed
US-11147788-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2021-10-19 US disclosed
US-20190183833-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA APS 2019-06-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11730714-B2 Compounds for the treatment of neuromuscular disorders RYR1, CACNB1, RYR2 LDHA 2645/4885PPARG 3332/4885PPARA 3247/4885
US-11147788-B2 Compounds for the treatment of neuromuscular disorders RYR1, CACNB1, RYR2 LDHA 2645/4885PPARG 3332/4885PPARA 3247/4885
US-20190183833-A1 Compounds For The Treatment Of Neuromuscular Disorders RYR1, CACNB1, RYR2 LDHA 2645/4885PPARG 3332/4885PPARA 3247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.