Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18100313 | 0.85 | NPC1 (0.42) | KMT2ANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL10654837 | 0.78 | NPC1 (0.49) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL28137726 | 0.78 | NPC1 (0.41) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL28574627 | 0.78 | NPC1 (0.41) | NOTUMMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11907198 | 0.77 | NPC1 (0.42) | CYP2D6MEN1RECQLKMT2ANPC1 | |
| SCHEMBL30129926 | 0.77 | NPC1 (0.42) | CYP2D6MEN1RECQLKMT2ANPC1 | |
| SCHEMBL28138209 | 0.75 | KDM4E (0.38) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL28579741 | 0.72 | MAPT (0.36) | NOTUMNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28569090 | 0.70 | MAPT (0.43) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL28915334 | 0.70 | NPC1 (0.42) | KMT2ANPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163740-B2 | 6-substituted benzoxazines | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |