Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16217460 | 0.95 | PRMT5 (0.76) | PRMT5WDR77 | |
| SCHEMBL16217449 | 0.90 | PRMT5 (0.67) | PRMT5WDR77 | |
| SCHEMBL16217443 | 0.90 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL15835834 | 0.90 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL16217439 | 0.90 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL16217538 | 0.89 | PRMT5 (0.78) | PRMT5WDR77 | |
| SCHEMBL21140473 | 0.89 | PRMT5 (0.78) | PRMT5WDR77 | |
| SCHEMBL16217467 | 0.87 | PRMT5 (0.77) | PRMT5WDR77 | |
| SCHEMBL21139542 | 0.86 | PRMT5 (0.64) | PRMT5WDR77 | |
| SCHEMBL16217516 | 0.86 | PRMT5 (0.64) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT3 | PRMT5 1/4885WDR77 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.