Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.72 |
| ▸ | BRD4 | O60885 | 1/20 | 0.72 |
| ▸ | IGF1R | P08069 | 13/20 | 0.68 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116462 | 0.82 | IGF1R (0.79) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL14650499 | 0.82 | KDR (0.63) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL6976835 | 0.81 | IGF1R (0.78) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL21067579 | 0.81 | IGF1R (0.58) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL6668581 | 0.79 | IGF1R (1.00) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL14634096 | 0.79 | KDR (0.57) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL590349 | 0.79 | KDR (0.49) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL30454194 | 0.79 | KDR (0.49) | KDRBRD4IGF1RCDK2EGFR | |
| SCHEMBL588511 | 0.78 | TNNI3K (0.49) | KDRBRD4IGF1REGFRFAM20C | |
| SCHEMBL31672486 | 0.78 | KDR (0.46) | KDRBRD4IGF1REGFRFAM20C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |