Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 1.00 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | QPCT | Q16769 | 3/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116462 | 0.84 | IGF1R (0.79) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL6645968 | 0.83 | IGF1R (1.00) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL6976835 | 0.83 | IGF1R (0.78) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL6980742 | 0.79 | FAM20C (0.78) | IGF1RKDRBRD4EGFRINSR | |
| Gw612286X SCHEMBL21067484 | 0.79 | KDR (0.72) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL31592617 | 0.78 | IGF1R (0.69) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL6967800 | 0.78 | IGF1R (0.71) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL31180291 | 0.78 | IGF1R (0.71) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL1116426 | 0.78 | IGF1R (0.74) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL6981464 | 0.78 | IGF1R (0.78) | IGF1RKDRBRD4EGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |