Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 1.00 |
| ▸ | IGF1R | P08069 | 4/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946510 | 0.82 | EPHB4 (0.69) | EPHB4IGF1RKDRAURKBPTK2 | |
| SCHEMBL14214721 | 0.81 | IGF1R (0.68) | EPHB4IGF1RKDRAURKBMEN1 | |
| SCHEMBL14214584 | 0.80 | IGF1R (0.66) | EPHB4IGF1RKDRAURKBMEN1 | |
| SCHEMBL6480192 | 0.79 | IGF1R (0.65) | EPHB4IGF1RKDRAURKBPTK2 | |
| SCHEMBL4829511 | 0.79 | MAPT (0.75) | EPHB4IGF1RMAPTMEN1KMT2A | |
| SCHEMBL4941396 | 0.78 | EPHB4 (0.64) | EPHB4IGF1RKDRAURKBMAPT | |
| SCHEMBL14214688 | 0.78 | EPHB4 (0.63) | EPHB4IGF1RKDRAURKBPTK2 | |
| SCHEMBL1927928 | 0.76 | IGF1R (0.61) | EPHB4IGF1RKDRAURKBMAPT | |
| SCHEMBL13955883 | 0.76 | IGF1R (0.59) | EPHB4IGF1RKDRAURKBPTK2 | |
| SCHEMBL2100643 | 0.76 | BCL6 (0.72) | EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |