⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29264498 | 0.71 | — | — | |
| SCHEMBL7103938 | 0.70 | — | — | |
| SCHEMBL7362923 | 0.66 | OR51E2 (0.33) | — | |
| SCHEMBL28575960 | 0.65 | — | — | |
| SCHEMBL2722664 | 0.65 | — | — | |
| SCHEMBL23152365 | 0.64 | — | — | |
| SCHEMBL2106928 | 0.64 | TLR4 (0.33) | — | |
| SCHEMBL1516176 | 0.64 | TLR4 (0.44) | — | |
| SCHEMBL29283789 | 0.63 | MAPT (0.36) | — | |
| SCHEMBL743262 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4092317-A | Preparation of quinoline derivatives | JOHN WYETH & BROTHER LIMITED (EN) | 1978-05-30 | — | — | US | claimed |
| CN-108524533-A | A kind of compound is used as antitumor drug synergist and reversal agent | 中国科学院动物研究所 | 2018-09-14 | — | — | CN | disclosed |
| CN-105712931-A | 7-phenyl-5-oxo-4-substituted-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid ethyl ester and non-catalyzed synthesis method thereof | 山东师范大学 | 2016-06-29 | — | — | CN | disclosed |
| CN-105712931-A | 7-phenyl-5-oxo-4-substituted-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid ethyl ester and non-catalyzed synthesis method thereof | 山东师范大学 | 2016-06-29 | — | — | CN | disclosed |
| US-8163768-B2 | 4-(4-Hydroxy-3-methyl-phenyl)-2,4,6,7,8,9-hexahydro-pyrazolo[3,4-b]-1,7-naphthyridin-5-one; inhibiting Aurora kinase; inhibiting the proliferation of tumor cells; cancer, psoriasis, leukaemia and lupus | AVENTIS PHARMA S.A.. (FR) | 2012-04-24 | — | — | US | disclosed |
| EP-1910366-B1 | 1,4-DIHYDROPYRIDINE-FUSED HETEROCYCLES, PROCESS FOR PREPARING THE SAME, USE AND COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2011-08-24 | — | — | EP | disclosed |
| US-20100298306-A1 | (1,4-Diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone Ligands for Nicotinic Acetylcholine Receptors, Useful for the Treatment of Disease | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-11-25 | — | — | US | disclosed |
| EP-2212321-A2 | (1,4-DIAZA-BICYCLO[3.2.2]NON-6-EN-4-YL)-HETEROCYCLYL-METHANONE LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, USEFUL FOR THE TREATMENT OF DISEASE | Memory Pharmaceuticals Corporation (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009055437-A9 | (1,4-DIAZA-BICYCLO[3.2.2]NON-6-EN-4-YL)-HETEROCYCLYL-METHANONE LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, USEFUL FOR THE TREATMENT OF DISEASE | MEMORY PHARM CORP (US) | 2009-07-23 | — | — | WO | disclosed |
| WO-2009055437-A2 | (1,4-DIAZA-BICYCLO[3.2.2]NON-6-EN-4-YL)-HETEROCYCLYL-METHANONE LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, USEFUL FOR THE TREATMENT OF DISEASE | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-04-30 | — | — | WO | disclosed |
| US-20080261969-A1 | 1,4-Dihydropyridine-Fused Heterocycles, Process for Preparing the Same, Use and Compositions Containing Them | AVENTIS PHARMA S.A. (FR) | 2008-10-23 | — | — | US | disclosed |
| EP-1910366-A2 | 1,4-DIHYDROPYRIDINE-FUSED HETEROCYCLES, PROCESS FOR PREPARING THE SAME, USE AND COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007012972-A2 | 1,4-DIHYDROPYRIDINE-FUSED HETEROCYCLES, PROCESS FOR PREPARING THE SAME, USE AND COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA S.A. (FR) | 2007-02-01 | — | — | WO | disclosed |
| US-4092317-A | Preparation of quinoline derivatives | JOHN WYETH & BROTHER LIMITED (EN) | 1978-05-30 | — | — | US | disclosed |
| US-4092317-A | Preparation of quinoline derivatives | JOHN WYETH & BROTHER LIMITED (EN) | 1978-05-30 | — | — | US | disclosed |