Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 14/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PYGM | P11217 | 1/20 | 0.44 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | IL2 | P60568 | 2/20 | 0.44 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606908 | 1.00 | PYGL (0.64) | PYGLROCK2ROCK1PYGMCYP51A1 | |
| SCHEMBL2108999 | 0.91 | PYGL (0.68) | PYGL | |
| SCHEMBL2107381 | 0.89 | ALB (0.55) | PYGLPYGMCYP51A1ALBIL2 | |
| SCHEMBL2107378 | 0.89 | ALB (0.55) | PYGLPYGMCYP51A1ALBIL2 | |
| SCHEMBL13271657 | 0.87 | PYGL (0.66) | PYGLROCK2ROCK1PYGMCYP51A1 | |
| SCHEMBL2606884 | 0.87 | PYGL (0.66) | PYGLROCK2ROCK1PYGMCYP51A1 | |
| SCHEMBL2106641 | 0.86 | PYGL (0.47) | PYGLPYGMCYP51A1ALBIL2 | |
| SCHEMBL2106640 | 0.86 | PYGL (0.47) | PYGLPYGMCYP51A1ALBIL2 | |
| SCHEMBL2606942 | 0.83 | CYP51A1 (0.56) | PYGLPYGMCYP51A1ALBIL2 | |
| SCHEMBL2109000 | 0.83 | PYGL (0.67) | PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158622-B2 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PROSIDION LIMITED (GB) | 2012-04-17 | — | — | US | disclosed |