Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.48 |
| ▸ | ROS1 | P08922 | 2/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 15/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31664109 | 0.93 | ALK (0.48) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL21069298 | 0.93 | ALK (0.48) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL31664262 | 0.91 | ALK (0.47) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL21069849 | 0.91 | ALK (0.47) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL21070683 | 0.90 | ALK (0.50) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL31664188 | 0.90 | ALK (0.50) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL21071950 | 0.89 | ALK (0.47) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL1706869 | 0.89 | ALK (0.52) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL21070436 | 0.88 | ALK (0.46) | ALKROS1MAPK3EGFRMET | |
| SCHEMBL31664087 | 0.88 | ALK (0.46) | ALKROS1MAPK3EGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230398223-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-12-14 | — | — | US | disclosed |
| US-11723980-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-08-15 | — | — | US | disclosed |
| US-20230106066-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
| US-11318205-B1 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-10874743-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2020-12-29 | — | — | US | disclosed |
| US-20190192668-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874743-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | ALK 83/4885ROS1 1084/4885MAPK3 1422/4885 |
| US-20230106066-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | ALK 83/4885ROS1 1084/4885MAPK3 1422/4885 |
| US-11723980-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | ALK 83/4885ROS1 1084/4885MAPK3 1422/4885 |
| US-20230398223-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | ALK 83/4885ROS1 1084/4885MAPK3 1422/4885 |
| US-20190192668-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | ALK 83/4885ROS1 1084/4885MAPK3 1422/4885 |
| US-11318205-B1 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | ALK 83/4885ROS1 1084/4885MAPK3 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.