Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19084006 | 0.89 | SCN9A (0.44) | SCN9ASCN7ASCN5AEPHX2 | |
| SCHEMBL19084009 | 0.89 | SCN9A (0.44) | SCN9ASCN7ASCN5AEPHX2 | |
| SCHEMBL21075343 | 0.88 | SCN9A (0.52) | SCN9AADRB2KMT2AMEN1SCN7A | |
| SCHEMBL19083806 | 0.86 | SCN9A (0.42) | SCN9ASCN7ASCN5A | |
| SCHEMBL23159346 | 0.85 | SCN9A (0.62) | SCN9ASCN7ASCN5A | |
| SCHEMBL23159322 | 0.82 | SCN9A (0.57) | SCN9ASCN7ASCN5A | |
| SCHEMBL21075477 | 0.80 | SCN9A (0.69) | SCN9ASCN7ASCN5AEPHX2 | |
| SCHEMBL16771206 | 0.77 | SCN9A (0.53) | SCN9AADRB2SCN7ASCN5AEPHX2 | |
| SCHEMBL21075216 | 0.77 | SCN9A (0.51) | SCN9AADRB2KMT2AMEN1SCN7A | |
| Hydrochloric Acid SCHEMBL17061970 | 0.77 | SCN9A (0.52) | SCN9AADRB2SCN7ASCN5AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |