Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25426591 | 0.84 | LMNA (0.38) | LMNAPOLBL3MBTL1DPP4FAP | |
| SCHEMBL25426588 | 0.84 | LMNA (0.38) | LMNAPOLBL3MBTL1DPP4FAP | |
| SCHEMBL14970428 | 0.83 | NAMPT (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31689901 | 0.83 | NAMPT (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10075387 | 0.83 | NAMPT (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL20228821 | 0.81 | DPP4 (0.40) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29039215 | 0.79 | HSD17B10 (0.46) | LMNAL3MBTL1 | |
| SCHEMBL26999205 | 0.79 | HSD17B10 (0.46) | LMNAL3MBTL1 | |
| SCHEMBL29410733 | 0.79 | HSD17B10 (0.46) | LMNAL3MBTL1 | |
| SCHEMBL20738584 | 0.78 | CHRM2 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |