Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17423077 | 0.84 | ALDH1A1 (0.42) | SCN9AALDH1A1NPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL17423109 | 0.84 | ALDH1A1 (0.42) | SCN9AALDH1A1NPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL17423116 | 0.83 | SCN9A (0.47) | SCN9AMAPTSCN1ASCN5ASCN2A | |
| SCHEMBL17423137 | 0.82 | ALDH1A1 (0.43) | SCN9AALDH1A1NPC1SCN1ASCN5A | |
| SCHEMBL17423136 | 0.82 | ALDH1A1 (0.43) | SCN9AALDH1A1NPC1SCN1ASCN5A | |
| SCHEMBL17423020 | 0.81 | SCN9A (0.45) | SCN9AALDH1A1MAPTSCN1ASCN5A | |
| SCHEMBL19064837 | 0.80 | SCN9A (0.38) | SCN9AMAPTSCN1ASCN5ASCN2A | |
| SCHEMBL19064838 | 0.80 | SCN9A (0.38) | SCN9AMAPTSCN1ASCN5ASCN2A | |
| SCHEMBL17423100 | 0.79 | SCN9A (0.38) | SCN9AMAPTSCN1ASCN5ASCN2A | |
| SCHEMBL19064836 | 0.77 | SCN9A (0.37) | SCN9AMAPTSCN1ASCN5ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |
| CN-106715418-A | Therapeutic compounds and methods of use thereof | 基因泰克公司 | 2017-05-24 | — | — | CN | disclosed |