Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.36 |
| ▸ | DPP4 | P27487 | 11/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075876 | 1.00 | SRC (0.41) | SRCDPP7DPP4DPP8DPP9 | |
| SCHEMBL24244437 | 0.94 | SRC (0.45) | SRCDPP7DPP4DPP8DPP9 | |
| SCHEMBL25716729 | 0.94 | SRC (0.45) | SRCDPP7DPP4DPP8DPP9 | |
| SCHEMBL8229987 | 0.80 | DPP4 (0.39) | SRCDPP7DPP4DPP8DPP9 | |
| SCHEMBL20399511 | 0.78 | SRC (0.42) | SRCDPP7DPP4JAK3MAPK1 | |
| SCHEMBL7857359 | 0.78 | SRC (0.42) | SRCDPP7DPP4DPP8DPP9 | |
| SCHEMBL13985445 | 0.78 | SRC (0.39) | SRCDPP4BTK | |
| SCHEMBL23080317 | 0.77 | HPGD (0.51) | SRCMAPK1GAAHPGD | |
| SCHEMBL23221995 | 0.77 | HPGD (0.51) | SRCMAPK1GAAHPGD | |
| SCHEMBL24064213 | 0.77 | SRC (0.41) | SRCDPP4JAK3MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023071973-A1 | FUSED BICYCLIC COMPOUND FOR INHIBITING ACTIVITY OF TYROSINE KINASE | SHENZHEN TARGETRX, INC. (CN) | 2023-05-04 | — | — | WO | disclosed |
| EP-3492471-B1 | FUSED BICYCLIC COMPOUND FOR INHIBITING ACTIVITY OF TYROSINE KINASE | SHENZHEN TARGETRX INC (CN) | 2020-12-02 | — | — | EP | disclosed |
| EP-3492471-A1 | FUSED BICYCLIC COMPOUND FOR INHIBITING ACTIVITY OF TYROSINE KINASE | Shenzhen Targetrx, Inc. (CN) | 2019-06-05 | — | — | EP | disclosed |