Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23080317 | 1.00 | HPGD (0.51) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL15049184 | 1.00 | HPGD (0.51) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL15049021 | 0.98 | HPGD (0.50) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL11931515 | 0.94 | SRC (0.45) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL20892969 | 0.94 | SRC (0.45) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL32667654 | 0.94 | SRC (0.45) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL11186138 | 0.82 | HPGD (0.53) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL29837045 | 0.81 | ALDH1A1 (0.57) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL25045294 | 0.79 | HPGD (0.50) | HPGDGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL22129575 | 0.79 | HPGD (0.50) | HPGDGAAALDH1A1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3318565-B1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES | PFIZER (US) | 2021-04-14 | — | — | EP | disclosed |