Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075927 | 0.88 | MAPK1 (0.66) | MAPK3MAPK1 | |
| SCHEMBL21075925 | 0.88 | MAPK3 (0.56) | MAPK3MAPK1AKT3 | |
| SCHEMBL21075939 | 0.87 | MAPK3 (0.46) | MAPK3MAPK1AKT3 | |
| SCHEMBL21075890 | 0.87 | MAPK3 (0.52) | MAPK3MAPK1AKT3 | |
| SCHEMBL21075870 | 0.86 | MAPK3 (0.52) | MAPK3MAPK1AKT3 | |
| SCHEMBL21075928 | 0.86 | MAPK3 (0.51) | MAPK3MAPK1 | |
| SCHEMBL21075880 | 0.86 | MAPK3 (0.62) | MAPK3MAPK1 | |
| SCHEMBL21075977 | 0.84 | MAPK3 (0.55) | MAPK3MAPK1 | |
| SCHEMBL21075929 | 0.84 | MAPK3 (0.53) | MAPK3MAPK1 | |
| SCHEMBL21075891 | 0.84 | MAPK3 (0.56) | MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237423-B1 | THIENO[2,3-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS | LILLY CO ELI (US) | 2019-06-05 | — | — | EP | disclosed |