Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075994 | 0.91 | MAPK3 (0.47) | MAPK1MAPK3JAK2KDRJAK3 | |
| SCHEMBL21075878 | 0.91 | MAPK3 (0.48) | MAPK1MAPK3JAK2KDRLCK | |
| SCHEMBL21075975 | 0.90 | MAPK1 (0.47) | MAPK1MAPK3FGFR1KDRCDK1 | |
| SCHEMBL21075927 | 0.84 | MAPK1 (0.66) | MAPK1MAPK3PIK3CAMAPK14CDK1 | |
| SCHEMBL21075880 | 0.81 | MAPK3 (0.62) | MAPK1MAPK3PIK3CAMAPK14CDK1 | |
| SCHEMBL17837218 | 0.80 | MAPK3 (0.51) | MAPK1MAPK3FGFR1NTRK1PIK3CA | |
| SCHEMBL17837268 | 0.79 | MAPK1 (0.73) | MAPK1MAPK3FGFR1JAK2KDR | |
| SCHEMBL21075891 | 0.78 | MAPK3 (0.56) | MAPK1MAPK3MAPK14CDK1 | |
| SCHEMBL23621135 | 0.78 | MAPK1 (0.51) | MAPK1MAPK3FGFR1JAK2KDR | |
| SCHEMBL21075977 | 0.78 | MAPK3 (0.55) | MAPK1MAPK3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237423-B1 | THIENO[2,3-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS | LILLY CO ELI (US) | 2019-06-05 | — | — | EP | disclosed |