Metanixin

Metanixin

SCHEMBL2107737

Cc1cccc(C)c1Nc1ncccc1C(=O)O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.78
GAA P10253 1/20 0.78
CLCN2 P51788 1/20 0.67
MEN1 O00255 6/20 0.63
KMT2A Q03164 6/20 0.63
RAB9A P51151 4/20 0.63
NPC1 O15118 3/20 0.63
MAPT P10636 1/20 0.63
DHODH Q02127 11/20 0.63
HDAC6 Q9UBN7 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
HTT P42858 3/20 0.56
ALDH1A1 P00352 2/20 0.56
NPSR1 Q6W5P4 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
PKM P14618 2/20 0.56
MAPK1 P28482 1/20 0.56
GMNN O75496 1/20 0.52
TTR P02766 1/20 0.52
CYP1A2 P05177 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3084057 0.90 CLCN2 (0.74) LMNAGAACLCN2MEN1KMT2A
SCHEMBL12082585 0.85 LMNA (0.80) LMNAGAACLCN2MEN1KMT2A
SCHEMBL12082596 0.84 LMNA (0.78) LMNAGAACLCN2MEN1KMT2A
Nixylic Acid SCHEMBL2733856 0.84 DHODH (0.76) LMNAGAACLCN2MEN1KMT2A
Nixylic Acid SCHEMBL31016400 0.84 DHODH (0.76) LMNAGAACLCN2MEN1KMT2A
SCHEMBL12082616 0.83 LMNA (0.70) LMNAGAACLCN2MEN1KMT2A
SCHEMBL11830229 0.81 HTT (0.60) LMNAGAACLCN2MEN1KMT2A
SCHEMBL24021545 0.80 CLCN2 (1.00) LMNAGAACLCN2MEN1KMT2A
SCHEMBL12082535 0.79 DHODH (0.78) LMNAGAAMEN1KMT2ARAB9A
SCHEMBL729207 0.78 DHODH (1.00) LMNAGAACLCN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-0130524-B1 DEPOT ANTIPHLOGISTICS Troponwerke GmbH & Co. KG (DE) 1989-08-23 EP claimed
US-4594357-A Depot antiinflammatory agents TROPONWERKE GMBH & CO. (DE) 1986-06-10 US claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
WO-1999053920-A1 USE OF VITAMIN PP COMPOUNDS KLINGE PHARMA GMBH (DE) 1999-10-28 WO disclosed
EP-0130524-B1 DEPOT ANTIPHLOGISTICS Troponwerke GmbH & Co. KG (DE) 1989-08-23 EP disclosed
EP-0132690-B1 THERMOPLASTICS CONTAINING ANTIPHLOGISTICS Troponwerke GmbH & Co. KG (DE) 1989-02-01 EP disclosed
EP-0201828-A2 Components for therapeutical drug delivery devices BAYER AG (DE) 1986-11-20 EP disclosed
EP-0132690-A1 Thermoplastics containing antiphlogistics Troponwerke GmbH & Co. KG (DE) 1985-02-13 EP disclosed
US-3959272-A ANALGESICS, ANTIINFLAMMATORY, PSYCHOTROPIC SOCIETE ANONYME DITE: HEXACHIME (FR) 1976-05-25 US disclosed