Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.74 |
| ▸ | AR | P10275 | 5/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11784128 | 0.92 | PGR (0.67) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11784119 | 0.92 | PGR (0.67) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11784124 | 0.92 | PGR (0.67) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11327063 | 0.91 | PGR (0.60) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11120558 | 0.91 | PGR (0.60) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11785707 | 0.90 | PGR (0.66) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11785717 | 0.90 | PGR (0.66) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11785713 | 0.90 | PGR (0.66) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11210514 | 0.88 | PGR (0.64) | PGRARADORA3ADRA1ACHRM1 | |
| SCHEMBL11338911 | 0.88 | PGR (0.64) | PGRARADORA3ADRA1ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178579-B1 | 5-AMINO-2,3-DIHYDRO-1,4-PHTHALAZINEDIONE AS GLUCOCORTICOID-SPARING AGENT | METRIOPHARM AG (CH) | 2025-02-12 | — | — | EP | claimed |
| CN-110418851-A | The treatment of cancer and diagnostic method | GENENTECH INC | 2019-11-05 | — | — | CN | disclosed |
| US-8158613-B2 | Topical pharmaceutical formulations and methods of treatment | PHARMAKODEX LIMITED (GB) | 2012-04-17 | — | — | US | disclosed |
| US-20100273760-A1 | Topical Pharmaceutical Formulations And Methods Of Treatment | PHARMAKODEX LIMITED (GB) | 2010-10-28 | — | — | US | disclosed |
| US-7754240-B2 | Solid at ambient temperature, softening point of </= 35 degrees C., when placed in continuous contact with skin it is softened to a consistency so substantial application of the unit dose is delivered in < 10 minutes | PHARMAKODEX LIMITED (GB) | 2010-07-13 | — | — | US | disclosed |
| US-20100034838-A1 | Transdermal Administration of Active Agents for Systemic Effect | STANIFORTH JOHN | 2010-02-11 | — | — | US | disclosed |
| US-20100016436-A1 | Transdermal Administration of Active Agents, in Particular Diclofenac | PHARMACODEX LTD. (GB) | 2010-01-21 | — | — | US | disclosed |
| US-20090304812-A1 | Topical Pharmaceutical Compositions | STANIFORTH JOHN | 2009-12-10 | — | — | US | disclosed |
| US-20090215753-A1 | Topical Compositions for Paediatric Use | PHARMACODEX LTD. (GB) | 2009-08-27 | — | — | US | disclosed |
| EP-1296652-B1 | TOPICAL PHARMACEUTICAL FORMULATIONS AND METHODS OF TREATMENT | PHARMAKODEX LTD (GB) | 2009-04-29 | — | — | EP | disclosed |
| WO-2007066149-A2 | TOPICAL PHARMACEUTICAL COMPOSITIONS | PHARMAKODEX LTD (GB) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007066148-A1 | TRANSDERMAL ADMINISTRATION OF ACTIVE AGENTS , IN PARTICULAR DICLOFENAC | PHARMAKODEX LTD (GB) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007066151-A2 | TOPICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY DISORDERS | PHARMAKODEX LTD (GB) | 2007-06-14 | — | — | WO | disclosed |
| CN-1438878-A | Topical pharmaceutical formulations and methods of treatment | VECTURA LTD (GB) | 2003-08-27 | — | — | CN | disclosed |
| US-20030138503-A1 | Solid at ambient temperature, softening point of </= 35 degrees C., when placed in continuous contact with skin it is softened to a consistency so substantial application of the unit dose is delivered in < 10 minutes | PHARMAKODEX LIMITED (GB) | 2003-07-24 | — | — | US | disclosed |
| EP-1296652-A1 | TOPICAL PHARMACEUTICAL FORMULATIONS AND METHODS OF TREATMENT | Vectura Limited (GB) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000203-A1 | TOPICAL PHARMACEUTICAL FORMULATIONS AND METHODS OF TREATMENT | VECTURA LIMITED (GB) | 2002-01-03 | — | — | WO | disclosed |
| EP-0561772-A1 | A new pharmaceutical use of fusidic acid and derivatives thereof | BENDTZEN, Klaus (DK) | 1993-09-29 | — | — | EP | disclosed |
| WO-1990004398-A1 | A NEW PHARMACEUTICAL USE OF FUSIDIC ACID AND DERIVATIVES THEREOF | BENDTZEN KLAUS (DK) | 1990-05-03 | — | — | WO | disclosed |
| US-4918065-A | ANTIINFLAMMATORY AGENT | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-04-17 | — | — | US | disclosed |