Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 6/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16554303 | 0.84 | JAK2 (0.50) | JAK1JAK2HTR2CKHKSIGMAR1 | |
| Hydrochloric Acid SCHEMBL16553729 | 0.84 | JAK2 (0.50) | JAK1JAK2HTR2CKHKSIGMAR1 | |
| SCHEMBL2640328 | 0.77 | JAK2 (0.65) | JAK1JAK2JAK3 | |
| SCHEMBL11029002 | 0.71 | HTR2C (0.42) | JAK1JAK2HTR2CKHKSIGMAR1 | |
| SCHEMBL24377330 | 0.70 | HTR2C (0.44) | JAK1JAK2HTR2CKHKSIGMAR1 | |
| SCHEMBL19659391 | 0.69 | JAK2 (0.53) | JAK2KDM4EALDH1A1HSD17B10JAK3 | |
| Hydrochloric Acid SCHEMBL9530706 | 0.69 | HTR2C (0.61) | HTR2CKHKSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL1366798 | 0.69 | HTR2C (0.61) | HTR2CKHKSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL21077885 | 0.69 | JAK1 (0.63) | JAK1JAK2 | |
| SCHEMBL20847736 | 0.67 | HTR2C (0.50) | HTR2CSIGMAR1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |