Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196984 | 0.84 | HTR2C (0.50) | HTR2CSIGMAR1CDK9KDM4EALDH1A1 | |
| SCHEMBL18278895 | 0.81 | HTR2C (0.50) | HTR2CSIGMAR1CDK9KDM4EALDH1A1 | |
| SCHEMBL20598454 | 0.80 | HTR2C (0.46) | HTR2CSIGMAR1CDK9KDM4EALDH1A1 | |
| SCHEMBL4004663 | 0.77 | SIGMAR1 (0.47) | HTR2CSIGMAR1CDK9KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3790021 | 0.76 | HTR2C (0.49) | HTR2CSIGMAR1CDK9KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9530706 | 0.76 | HTR2C (0.61) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| SCHEMBL1366798 | 0.76 | HTR2C (0.61) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL15006828 | 0.75 | HTR2C (0.55) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| SCHEMBL38661232 | 0.75 | HTR2C (0.49) | HTR2CSIGMAR1CDK9KDM4EALDH1A1 | |
| SCHEMBL12537881 | 0.75 | L3MBTL1 (0.45) | HTR2CSIGMAR1CDK9DRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164395-B1 | INDANE AND INDOLINE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | NOVARTIS AG (CH) | 2019-03-27 | — | — | EP | disclosed |