Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | STK17B | O94768 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22996206 | 0.87 | CA1 (0.54) | GAACA1CA2TDP1SIGMAR1 | |
| SCHEMBL22996211 | 0.87 | CA1 (0.54) | LMNAGAACA1CA2TDP1 | |
| SCHEMBL7465537 | 0.87 | ESRRG (0.58) | GAACA1CA2TDP1SIGMAR1 | |
| SCHEMBL22996123 | 0.86 | SMN1; SMN2 (0.54) | LMNAGAACA1CA2TDP1 | |
| SCHEMBL31307112 | 0.85 | TDP1 (0.54) | GAACA1CA2TDP1SIGMAR1 | |
| SCHEMBL2551512 | 0.85 | CA1 (0.53) | LMNAGAACA1CA2TDP1 | |
| SCHEMBL4039313 | 0.85 | CA1 (0.56) | GAACA1CA2TDP1SIGMAR1 | |
| SCHEMBL3437047 | 0.85 | GAA (0.56) | GAACA1CA2TDP1SIGMAR1 | |
| SCHEMBL8381122 | 0.85 | CA1 (0.53) | GAACA1CA2TDP1SIGMAR1 | |
| SCHEMBL6833896 | 0.85 | CA1 (0.53) | GAACA1CA2TDP1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |