Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.57 |
| ▸ | JAK3 | P52333 | 17/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23030108 | 0.81 | JAK2 (0.56) | JAK2JAK3PTK2HSD17B10KDM4E | |
| SCHEMBL13535757 | 0.81 | AHR (0.50) | JAK2JAK3PTK2ALDH1A1 | |
| SCHEMBL19226350 | 0.79 | JAK2 (0.53) | JAK2JAK3PTK2KDM4EALDH1A1 | |
| SCHEMBL21078299 | 0.79 | JAK2 (0.53) | JAK2JAK3PTK2KDM4EALDH1A1 | |
| SCHEMBL24857421 | 0.77 | JAK2 (0.42) | JAK2JAK3PTK2 | |
| SCHEMBL3759958 | 0.73 | JAK2 (1.00) | JAK2JAK3PTK2 | |
| SCHEMBL2640482 | 0.73 | JAK2 (0.54) | JAK2JAK3PTK2KDM4EALDH1A1 | |
| SCHEMBL18952791 | 0.73 | JAK2 (0.47) | JAK2JAK3PTK2KDM4EALDH1A1 | |
| SCHEMBL2634635 | 0.72 | JAK2 (1.00) | JAK2JAK3PTK2 | |
| SCHEMBL1857805 | 0.70 | JAK2 (0.75) | JAK2JAK3PTK2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |