Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896812 | 0.81 | MAP4K4 (0.52) | HRH3MAP4K4DCPSFDPSMEN1 | |
| SCHEMBL21178480 | 0.80 | MAP4K4 (0.46) | HRH3MAP4K4FDPSMEN1KMT2A | |
| SCHEMBL13621199 | 0.80 | MAP4K4 (0.47) | HRH3MAP4K4DCPSKCNH2FDPS | |
| SCHEMBL21058810 | 0.78 | BRD4 (0.43) | HRH3MAP4K4KCNH2FDPSMEN1 | |
| SCHEMBL20328914 | 0.77 | EGLN1 (0.44) | DCPSSCN9AMEN1KMT2A | |
| SCHEMBL1332937 | 0.77 | EGLN1 (0.44) | DCPSSCN9AMEN1KMT2A | |
| SCHEMBL12090434 | 0.75 | MAP4K4 (0.54) | HRH3MAP4K4KCNH2FDPSPRMT6 | |
| SCHEMBL17896402 | 0.75 | MAP4K4 (0.47) | HRH3MAP4K4DCPSFDPSMEN1 | |
| SCHEMBL28251948 | 0.73 | MAP4K4 (0.40) | MAP4K4DCPSFDPSMEN1KMT2A | |
| SCHEMBL2606179 | 0.71 | DCPS (0.46) | HRH3DCPSSCN9AKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |