Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.76 |
| ▸ | JAK3 | P52333 | 11/20 | 0.49 |
| ▸ | JAK2 | O60674 | 10/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19823053 | 0.89 | JAK1 (0.80) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL19823063 | 0.88 | JAK1 (0.76) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL24062643 | 0.86 | JAK1 (0.75) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL21044831 | 0.86 | JAK1 (1.00) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL22110347 | 0.86 | JAK1 (1.00) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL21044810 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL24062654 | 0.78 | JAK1 (0.80) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL24062733 | 0.76 | JAK1 (0.56) | JAK1JAK3JAK2PTK2PSEN1 | |
| SCHEMBL19823046 | 0.76 | JAK1 (0.77) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL19823062 | 0.76 | JAK1 (0.75) | JAK1JAK3JAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492469-A1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |