Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 12/20 | 0.49 |
| ▸ | BTK | Q06187 | 3/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19823106 | 0.87 | JAK2 (0.55) | IKBKBCHUKJAK2BTKTYRO3 | |
| SCHEMBL19823105 | 0.83 | MAP3K11 (0.53) | IKBKBCHUKJAK2BTKFLT3 | |
| SCHEMBL19823110 | 0.83 | CSF1R (0.55) | IKBKBCHUKJAK2BTKTYRO3 | |
| SCHEMBL19823104 | 0.82 | JAK2 (0.50) | IKBKBCHUKJAK2BTKTYRO3 | |
| SCHEMBL19823108 | 0.81 | IKBKB (0.51) | IKBKBCHUKJAK2TYRO3JAK3 | |
| SCHEMBL19823052 | 0.81 | JAK1 (0.49) | IKBKBCHUKJAK2BTKTYRO3 | |
| SCHEMBL21044826 | 0.75 | JAK2 (0.60) | IKBKBCHUKJAK2BTKTYRO3 | |
| SCHEMBL16793627 | 0.74 | JAK2 (0.66) | IKBKBCHUKJAK2BTKTYRO3 | |
| SCHEMBL19823047 | 0.71 | TNIK (0.49) | JAK2JAK3FLT3DAPK3PRKD3 | |
| SCHEMBL15661177 | 0.71 | JAK2 (0.70) | IKBKBCHUKJAK2BTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492469-B1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | SUZHOU LONGBIOTECH PHARMACEUTICALS CO LTD (CN) | 2021-12-01 | — | — | EP | disclosed |
| EP-3492469-A1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |