Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.45 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PRKACA | P17612 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19823045 | 0.87 | TNIK (0.54) | TNIKCAMKK2OPRM1HTR2AMAP3K11 | |
| SCHEMBL19823067 | 0.84 | TNIK (0.68) | TNIKMAP3K11MAP3K9ROCK2CDK2 | |
| SCHEMBL19823044 | 0.84 | LRRK2 (0.59) | TNIKCAMKK2OPRM1HTR2ADRD4 | |
| SCHEMBL19823109 | 0.83 | TNIK (0.53) | TNIKCAMKK2OPRM1HTR2AMAP3K11 | |
| SCHEMBL19823108 | 0.83 | IKBKB (0.51) | PRKACAMAP4K4DYRK1BCLK4DAPK3 | |
| SCHEMBL19823048 | 0.82 | TNIK (0.52) | TNIKCAMKK2OPRM1HTR2AMAP3K11 | |
| SCHEMBL21044844 | 0.77 | CAMKK2 (0.54) | TNIKCAMKK2ROCK2PIM1PRKACA | |
| SCHEMBL31258374 | 0.75 | CNR2 (0.55) | TNIKCAMKK2OPRM1HTR2ADRD4 | |
| SCHEMBL14620845 | 0.73 | CAMKK2 (0.62) | CAMKK2ROCK2PIM1PRKACACDK2 | |
| SCHEMBL858766 | 0.72 | CAMKK2 (0.64) | CAMKK2ROCK2PIM1PRKACACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492469-A1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018019223-A1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | 张文燕 | 2018-02-01 | — | — | WO | disclosed |