Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12074207 | 0.74 | KDM4E (0.48) | KDM4EPARP1ALDH1A1HSD17B10HPGD | |
| SCHEMBL12074205 | 0.69 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10HPGDPKM | |
| SCHEMBL6845090 | 0.68 | KDM4E (0.58) | KDM4EPARP1ALDH1A1HSD17B10HPGD | |
| SCHEMBL2193298 | 0.66 | PARP1 (0.54) | KDM4EPDGFRACSNK1A1CDK8CDK5 | |
| SCHEMBL12072817 | 0.65 | S1PR2 (0.46) | KDM4EALDH1A1MEN1S1PR2MAPT | |
| SCHEMBL1719969 | 0.64 | PARP1 (0.53) | KDM4EPARP1HSD17B10HPGD | |
| SCHEMBL12073695 | 0.64 | S1PR2 (0.46) | KDM4EALDH1A1MEN1S1PR2MAPT | |
| SCHEMBL15295901 | 0.64 | S1PR2 (0.48) | KDM4EALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL25976835 | 0.62 | PDE10A (0.35) | MEN1S1PR2MAPTGLP1RKMT2A | |
| SCHEMBL1695316 | 0.62 | HSD17B10 (0.40) | KDM4EALDH1A1HSD17B10HPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858358-B2 | S1PR2 antagonists and uses therefor | DALHOUSIE UNIVERSITY (CA) | 2020-12-08 | — | — | US | disclosed |
| US-10487082-B2 | S1PR2 antagonists and uses therefor | DALHOUSIE UNIVERSITY (CA) | 2019-11-26 | — | — | US | disclosed |
| US-20190169187-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858358-B2 | S1PR2 antagonists and uses therefor | S1PR2, S1PR4, S1PR1 | KDM4E 1437/4885CHEK1 4001/4885AURKA 4070/4885 |
| US-20190169187-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR3 | KDM4E 2726/4885CHEK1 4169/4885AURKA 3291/4885 |
| US-10487082-B2 | S1PR2 antagonists and uses therefor | S1PR2, S1PR4, S1PR3 | KDM4E 2726/4885CHEK1 4169/4885AURKA 3291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.