SCHEMBL21083000

SCHEMBL21083000

Cc1nc2ccc(Cl)cc2c(-c2ccccc2)c1C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 6/20 1.00
FABP3 P05413 5/20 1.00
PRNP P04156 1/20 0.71
PPARG P37231 1/20 0.71
RXFP1 Q9HBX9 1/20 0.71
NR2E3 Q9Y5X4 1/20 0.71
NCOR2 Q9Y618 1/20 0.71
FABP5 Q01469 5/20 0.70
KDM4E B2RXH2 1/20 0.67
PLA2G2A P14555 1/20 0.65
DHODH Q02127 2/20 0.61
ALDH1A1 P00352 2/20 0.59
GAA P10253 2/20 0.56
CYP2C9 P11712 2/20 0.56
NPSR1 Q6W5P4 2/20 0.55
MAPT P10636 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.52
LMNA P02545 1/20 0.51
MAP2 P11137 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2820951 0.90 FABP4 (0.82) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL10659362 0.88 FABP4 (0.79) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL3322903 0.85 FABP4 (0.73) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL14916797 0.84 FABP4 (0.73) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL3318172 0.84 FABP4 (0.72) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL12497003 0.83 FABP4 (0.71) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL14917093 0.83 FABP4 (1.00) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL27658279 0.82 GAA (0.77) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL3322283 0.82 FABP4 (0.69) FABP4FABP3PRNPPPARGRXFP1
SCHEMBL8132130 0.81 FABP4 (0.68) FABP4FABP3PRNPPPARGRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116761598-A Antiviral use of FABP4 modulating compounds 新月生物科学 2023-09-15 CN claimed
US-20230255933-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS CRESCENTA BIOSCIENCES (US) 2023-08-17 US claimed
US-20230241025-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS CRESCENTA BIOSCIENCES (US) 2023-08-03 US claimed
EP-4175647-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS Crescenta Biosciences (US) 2023-05-10 EP claimed
WO-2022010951-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS CRESCENTA BIOSCIENCES (US) 2022-01-13 WO claimed
US-12138243-B2 Antiviral use of FABP4 modulating compounds CRESCENTA BIOSCIENCES (US) 2024-11-12 US disclosed
CN-116761598-A Antiviral use of FABP4 modulating compounds 新月生物科学 2023-09-15 CN disclosed
US-20230255933-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS CRESCENTA BIOSCIENCES (US) 2023-08-17 US disclosed
US-20230241025-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS CRESCENTA BIOSCIENCES (US) 2023-08-03 US disclosed
EP-4175647-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS Crescenta Biosciences (US) 2023-05-10 EP disclosed
US-11229624-B2 FABP4 as a therapeutic target in skin diseases TICURE LTD. (IL) 2022-01-25 US disclosed
WO-2022010951-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS CRESCENTA BIOSCIENCES (US) 2022-01-13 WO disclosed
US-20200138779-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES TICURE LTD. (IL) 2020-05-07 US disclosed
US-20190201376-A1 Method for Treating or Preventing Fatty Acid Binding Protein 3 Induced B-amyloid Aggregation Diseases NATIONAL TAIWAN NORMAL UNIVERSITY (TW) 2019-07-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230241025-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS FABP1, FABP4, FABP5 FABP4 2/4885FABP3 4/4885PRNP 2761/4885
US-12138243-B2 Antiviral use of FABP4 modulating compounds FABP1, FABP5, FABP4 FABP4 3/4885FABP3 4/4885PRNP 1487/4885
US-11229624-B2 FABP4 as a therapeutic target in skin diseases FABP4, FABP2, FABP1 FABP4 1/4885FABP3 5/4885PRNP 4562/4885
US-20200138779-A1 FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES FABP4, FABP2, FABP1 FABP4 1/4885FABP3 5/4885PRNP 4562/4885
US-20230255933-A1 ANTIVIRAL USE OF FABP4 MODULATING COMPOUNDS FABP1, FABP4, FABP5 FABP4 2/4885FABP3 4/4885PRNP 1650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.