Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21083456 | 0.89 | NPC1 (0.44) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL23931046 | 0.84 | HRH3 (0.54) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL14820046 | 0.82 | KDM5A (0.46) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL14805822 | 0.80 | KDM5A (0.44) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL18487764 | 0.76 | KDM5A (0.41) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL21084204 | 0.75 | — | — | |
| SCHEMBL22372243 | 0.75 | HRH3 (0.46) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL11033825 | 0.74 | GAA (0.51) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL18912370 | 0.74 | SMN1; SMN2 (0.40) | NPC1RAB9ATP53SMN1; SMN2HRH3 | |
| SCHEMBL21268151 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101198594-A | Process for the production of intermadiates for the preparation of tricyclic benzimidazoles | NYCOMED GMBH (DE) | 2008-06-11 | — | — | CN | claimed |
| CN-100393720-C | Cyclic benzimidazoles. | ALTANA PHARMA AG (DE) | 2008-06-11 | — | — | CN | claimed |
| US-11466003-B2 | Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2022-10-11 | — | — | US | disclosed |
| US-20210300916-A1 | NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2021-09-30 | — | — | US | disclosed |
| EP-3492461-A1 | NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | Shanghai Yingli Pharmaceutical Co. Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |
| CN-101198594-A | Process for the production of intermadiates for the preparation of tricyclic benzimidazoles | NYCOMED GMBH (DE) | 2008-06-11 | — | — | CN | disclosed |
| CN-100393720-C | Cyclic benzimidazoles. | ALTANA PHARMA AG (DE) | 2008-06-11 | — | — | CN | disclosed |
| CN-1764662-A | Cyclic benzimidazoles. | ALTANA PHARMA AG (DE) | 2006-04-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11466003-B2 | Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof | NOTUM, ALKBH5, PAH | NPC1 541/4885RAB9A 3806/4885TP53 2272/4885 |
| US-20210300916-A1 | NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | NOTUM, ALKBH5, PAH | NPC1 541/4885RAB9A 3806/4885TP53 2272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.