ALKBH5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL693015	0.73	17/20
SCHEMBL67421	0.66	17/20
SCHEMBL693103	0.64	17/20
SCHEMBL692998	0.64	17/20
SCHEMBL691280	0.57	17/20
SCHEMBL691653	0.51	15/20
SCHEMBL699241	0.41	11/20
SCHEMBL697599	0.43	10/20
SCHEMBL691604	0.47	9/20
SCHEMBL693273	0.40	9/20
SCHEMBL394287	0.51	8/20
SCHEMBL692614	0.50	8/20
SCHEMBL395368	0.40	8/20
SCHEMBL693181	0.40	7/20
SCHEMBL486157	0.40	7/20
SCHEMBL699253	0.36	7/20
SCHEMBL407942	0.64	5/20
SCHEMBL393039	0.46	5/20
SCHEMBL486125	0.42	5/20
SCHEMBL692284	0.46	4/20

Clinical trials — most relevant to ALKBH5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Randomized Study of Decitabine in Maintenance Therapy of Acute Myeloid Leukemia (AML)	PHASE2/PHASE3	COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis	PHASE1/PHASE2	RECRUITING
A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma	PHASE1	RECRUITING
Testing the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel) and Immunotherapy (Pembrolizumab) for Metastatic Triple-Negative Breast Cancer	PHASE1	SUSPENDED
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors	PHASE1	RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)	nan	UNKNOWN
Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery	nan	RECRUITING
Prognosis of METTL-14 in Endometrial Carcinoma	nan	NOT_YET_RECRUITING
Expression of TET1 Gene in Acute Leukaemia	nan	UNKNOWN
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study	nan	NOT_YET_RECRUITING
Using the Epitranscriptome to Diagnose and Treat Gliomas	nan	RECRUITING
Impact of Weight Loss on the Human Sperm Epitranscriptome	nan	ACTIVE_NOT_RECRUITING
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC	nan	UNKNOWN
The Crosstalk Between the Epigenome and Mitochondria in SCI	nan	NOT_YET_RECRUITING
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
DNA Methylation and Autoimmune Thyroid Diseases	nan	COMPLETED
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Molecular Characterization of Acute Erythroid Leukemia (M6-AML) Using Targeted Next-generation Sequencing	nan	COMPLETED
Adenosylmethionine Metabolism in Human Inflammation	nan	UNKNOWN
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Molecular Profiling for Risk Stratification in Appendiceal Cancer	nan	RECRUITING
Residual Hypermethylation in Early Stage Non-Small Cell Lung Cancer (NSCLC) As Part of Adjuvant Therapy and Preventive Strategy	nan	COMPLETED
The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ALKBH5 binder may also engage these)

Protein	Name	Similarity
D3ZKD3	—	1.000	D3ZKD3 →
Q3TSG4	—	1.000	Q3TSG4 →
E1BH29	—	1.000	E1BH29 →
Q6GPB5	—	0.996	Q6GPB5 →
Q66JG8	—	0.991	Q66JG8 →
Q08BA6	—	0.986	Q08BA6 →
Q6NRE7	—	0.967	Q6NRE7 →
P49140	—	0.967	P49140 →
Q80TJ7	—	0.966	Q80TJ7 →
Q69ZT9	—	0.966	Q69ZT9 →
Q5CD77	—	0.966	Q5CD77 →
Q95168	—	0.966	Q95168 →
Q4KUS2	—	0.966	Q4KUS2 →
Q9H8E8	—	0.966	Q9H8E8 →
Q9Z1N9	—	0.965	Q9Z1N9 →
Q8CID0	—	0.965	Q8CID0 →
Q9UPW8	—	0.965	Q9UPW8 →
Q62768	—	0.965	Q62768 →
Q8K4S7	—	0.965	Q8K4S7 →
Q6ZWB6	—	0.965	Q6ZWB6 →
Q5R6Y9	—	0.964	Q5R6Y9 →
Q9UDY2	—	0.964	Q9UDY2 →
Q50H33	—	0.964	Q50H33 →
Q8VYN2	—	0.964	Q8VYN2 →
Q9WTU0	—	0.964	Q9WTU0 →
P39447	—	0.964	P39447 →
B2RUR8	—	0.964	B2RUR8 →
Q9P2M4	—	0.964	Q9P2M4 →
Q8K1N4	—	0.964	Q8K1N4 →
Q28C33	—	0.964	Q28C33 →