Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.63 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.63 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.55 |
| ▸ | CCNK | O75909 | 2/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 8/20 | 0.48 |
| ▸ | JAK1 | P23458 | 6/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99868 | 0.87 | AURKB (0.59) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL28107488 | 0.85 | AURKB (0.57) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL29540487 | 0.85 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL101177 | 0.85 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL18602404 | 0.85 | AURKB (0.57) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL15389485 | 0.84 | AURKB (0.56) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL99736 | 0.84 | AURKB (0.56) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL18599173 | 0.84 | AURKB (0.56) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL99992 | 0.83 | AURKA (0.52) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL13541161 | 0.83 | AURKB (0.63) | AURKBAURKAINCENPTPX2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492468-B1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | SUZHOU LONGBIOTECH PHARMACEUTICALS CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |
| EP-2343298-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-3492468-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |