Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.57 |
| ▸ | AURKA | O14965 | 4/20 | 0.57 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.57 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 6/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 5/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540487 | 0.91 | AURKB (0.60) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL101177 | 0.91 | AURKB (0.60) | AURKBAURKAINCENPTPX2JAK2 | |
| Trifluoroacetic Acid SCHEMBL4094031 | 0.88 | JAK2 (0.54) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL15389320 | 0.87 | AURKB (0.52) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL99992 | 0.87 | AURKA (0.52) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL100576 | 0.86 | AURKB (0.62) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL21085376 | 0.85 | AURKB (0.63) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL21320196 | 0.85 | JAK2 (0.75) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL99868 | 0.84 | AURKB (0.59) | AURKBAURKAINCENPTPX2JAK2 | |
| SCHEMBL101852 | 0.84 | AURKA (0.54) | AURKBAURKAINCENPTPX2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254190-B | Heteroaryl substituted pyrrolo-[2,3-b] pyridine and pyrrolo-[2,3-b] pyrimidine as Janus inhibitors of kinases | 因塞特控股公司 | 2016-12-07 | — | — | CN | disclosed |