Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CTBP2 | P56545 | 4/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21087161 | 0.87 | HDAC1 (0.36) | CYP1A2CYP2C19CTBP2CES1NR1H4 | |
| SCHEMBL18751676 | 0.81 | CYP1A2 (0.46) | CYP1A2CYP2C19CTBP2CES1NR1H4 | |
| SCHEMBL13272059 | 0.79 | PPARG (0.40) | CYP1A2CYP2C19CES1PPARGPPARA | |
| SCHEMBL13589436 | 0.78 | PPARA (0.41) | PPARGPPARAMEN1ALDH1A1KMT2A | |
| SCHEMBL15042247 | 0.75 | SIGMAR1 (0.38) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL18116097 | 0.75 | CYP1A2 (0.57) | CYP1A2CYP2C19CES1NR1H4ALDH1A1 | |
| SCHEMBL21087169 | 0.74 | HDAC8 (0.45) | CTBP2CES1PPARGHPGD | |
| SCHEMBL13012059 | 0.73 | CTBP2 (0.54) | CTBP2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27453005 | 0.73 | FOLH1 (0.53) | ALDH1A1KMT2A | |
| SCHEMBL13012102 | 0.72 | CTBP2 (0.51) | CYP1A2CYP2C19CTBP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190175744-A1 | INSULIN-INCRETIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190175744-A1 | INSULIN-INCRETIN CONJUGATES | GIPR, GLP1R, GCGR | CYP1A2 3977/4885CYP2C19 4050/4885CTBP2 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.