Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | AGXT | P21549 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31175766 | 0.83 | ADRA2B (0.50) | ADRA2BIDO1MAPTTSHRAGXT | |
| SCHEMBL26037690 | 0.83 | ADRA2B (0.50) | ADRA2BIDO1MAPTTSHRAGXT | |
| SCHEMBL7239671 | 0.81 | TAAR1 (0.54) | ADRA2BMAPTMAPK1TDP1TAAR1 | |
| SCHEMBL12844067 | 0.81 | TAAR1 (0.38) | ADRA2BIDO1MAPTTSHRMAPK1 | |
| SCHEMBL4332045 | 0.81 | ADRA2B (0.49) | ADRA2BIDO1MAPTTSHRAGXT | |
| Hydrochloric Acid SCHEMBL1161200 | 0.79 | ADRA2B (0.47) | ADRA2BIDO1MAPTTSHRAGXT | |
| SCHEMBL377462 | 0.79 | ADRA2B (0.47) | ADRA2BIDO1MAPTTSHRAGXT | |
| SCHEMBL5923845 | 0.79 | ADRA2B (0.47) | ADRA2BIDO1MAPTTSHRAGXT | |
| SCHEMBL22384566 | 0.79 | ADRA2B (0.47) | ADRA2BIDO1MAPTTSHRAGXT | |
| SCHEMBL12983255 | 0.79 | ADRA2B (0.47) | ADRA2BIDO1MAPTTSHRAGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |