ADRA2B

Alpha-2B adrenergic receptor · P18089 · ADRA2B on Sugi Atlas →

339,088 patent compounds predicted against ADRA2B, 237,294 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Brimonidine (SCHEMBL24670)	1.00	19/20
Dexmedetomidine (SCHEMBL26433)	1.00	11/20
Clonidine (SCHEMBL5983)	1.00	10/20
Prochlorperazine (SCHEMBL18429)	1.00	6/20
Bisantrene (SCHEMBL4773)	0.44	6/20
Ergotamine (SCHEMBL1483)	1.00	5/20
Carbinoxamine (SCHEMBL5070)	1.00	5/20
Amitriptyline (SCHEMBL7824)	1.00	5/20
Oxymetazoline (SCHEMBL24301)	1.00	5/20
Yohimbine (SCHEMBL33954)	1.00	5/20
Yohimbine (SCHEMBL33955)	1.00	5/20
Ergotamine (SCHEMBL8045)	0.93	5/20
Ergotamine (SCHEMBL8046)	0.93	5/20
Bisantrene (SCHEMBL7472)	0.43	5/20
Dexchlorpheniramine (SCHEMBL3538)	1.00	4/20
Chlorpheniramine (SCHEMBL4219)	1.00	4/20
Chlorpheniramine (SCHEMBL4220)	1.00	4/20
Ketotifen (SCHEMBL4436)	1.00	4/20
Phenylephrine (SCHEMBL4711)	1.00	4/20
Phenylephrine (SCHEMBL4712)	1.00	4/20

Clinical trials — most relevant to ADRA2B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences	PHASE4	RECRUITING
Reversal of Acute β-Blocker Induced Bronchoconstriction	PHASE4	COMPLETED
Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma	PHASE3	COMPLETED
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure	PHASE3	COMPLETED
Efficacy of Dexmedetomidine As an Adjuvant to Bupivacaine in Pericapsular Nerve Group Block in Hip Replacement Surgeries	PHASE2	NOT_YET_RECRUITING
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
Analgesia After Laparoscopic Cholecystectomy	PHASE2	UNKNOWN
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children	PHASE1	COMPLETED
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
Beta-Blockers on Neoadjuvant Immunochemotherapy for Hypertensive Patients With Gastric Cancer	nan	ACTIVE_NOT_RECRUITING
Influence of Nebivolol on Postmenopausal Women	nan	UNKNOWN
Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA	nan	RECRUITING
Effect of Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults	nan	ACTIVE_NOT_RECRUITING
Ultrasound Guided Rectus Sheath Block and Transversus Abdominis Plane Block	nan	COMPLETED
Genetic Determinants of Response to Beta Blockade	nan	COMPLETED
Comparative Study Between Behavior Therapy and Behavior Therapy Plus Mirabegron in Sexually Active Men With OAB Symptoms	nan	COMPLETED
Add-on Salmeterol Versus Montelukast in Arg/Arg-16 Asthmatics	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Superficial Cervical Plexus Block With Dexmedetomidine Versus Without Adjuvant in Thyroid Surgery	nan	COMPLETED
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension	nan	COMPLETED
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADRA2B binder may also engage these)

Protein	Name	Similarity
Q60475	—	1.000	Q60475 →
P19328	—	1.000	P19328 →
P30545	—	1.000	P30545 →
O77700	—	0.998	O77700 →
O77830	—	0.998	O77830 →
O77723	—	0.997	O77723 →
O19025	—	0.997	O19025 →
O77721	—	0.997	O77721 →
O19012	—	0.996	O19012 →
O77715	—	0.996	O77715 →
O19032	—	0.996	O19032 →
O77713	—	0.996	O77713 →
O18935	—	0.995	O18935 →
Q28838	—	0.994	Q28838 →
O19054	—	0.993	O19054 →
P22909	—	0.992	P22909 →
Q6XXX9	—	0.992	Q6XXX9 →
O19014	—	0.991	O19014 →
O19091	—	0.991	O19091 →
P18871	—	0.990	P18871 →
Q6XXY0	—	0.990	Q6XXY0 →
Q60474	—	0.990	Q60474 →
Q01338	—	0.989	Q01338 →
Q5IS72	—	0.987	Q5IS72 →
P25115	—	0.987	P25115 →
HTR1A	5-hydroxytryptamine receptor 1A	0.987	landscape →
P97717	—	0.987	P97717 →
Q91175	—	0.987	Q91175 →
P23944	—	0.986	P23944 →
ADRA2A	Alpha-2A adrenergic receptor	0.986	landscape →